Web3 Jul 2024 · The phosphatase and tensin homolog is a protein encoded by the PTEN gene. PTEN maps to chromosome 10q23.3 and has been thoroughly investigated as a dormant tumor suppressor [ 5 – 7 ]. PTEN has been demonstrated to be a component of signal transduction pathways involved in the regulation of cell growth, proliferation, and … Web4 Apr 2024 · Summary. This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein …
Regulation of PTEN (Phosphatase and Tensin Homolog Deleted …
Web微小RNA(microRNA,miRNA,miR)是一类进化上高度保守长度为18~24个核苷酸的非编码RNA。miRNA可通过与靶基因3’端非编码区(3′untranslated regions,3’UTR)结合,导致靶基因的降解或抑制其翻译 [] 。 有研究结果表明,miR-221在多种类型的癌症中表达增加,包括胶质母细胞瘤、肝癌、胃癌、乳腺癌以及前列腺癌 ... http://www.a-hospital.com/w/%E7%BB%86%E8%83%9E%E8%BF%81%E7%A7%BB tack hammer tool
PDK1 S53/55位点作为靶标在制备乳腺癌治疗药物中的应用
Web22 Feb 2016 · Bioinformatics analysis, luciferase reporter gene assays, and western blotting showed that phosphatase and tensin homolog (PTEN) was a target of miR-221 and could block IL-4 secretion stimulated by miR-221. The phosphorylation of p38 (protein) and activity of nuclear factor-kappaB (NF-κB) were increased after overexpression of miR-221, as ... Web1 Dec 2024 · Although statistically significant in univariate analyses, phosphatase and tensin homolog was no longer significant after adjustment for Cancer of the Prostate Risk Assessment Post-Surgical. Analysis of interaction with National Comprehensive Cancer Network risk group showed that cell-cycle progression had the strongest effect among … WebTensin. Tensin is a cell-matrix adhesion protein binding the integrins and cytoskeletal actin filaments that also interacts with PI3-kinase and the JNK pathway. From: Polyphenols: … tack games