WebSearch the Townsend-Lab-Yale/cancereffectsizeR package. Vignettes. README.md WebAuthor(s): Siu, Kin; Lotz, Christopher; Ping, Peipei; Cai, Hua Abstract: Despite an established role of mitochondrial dysfunction in cardiac ischemia/reperfusion (I/R) injury, the upstream activators have remained incompletely defined. We have recently identified an innovative role of exogenously applied netrin-1 in cardioprotection, which is mediated by …
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WebAug 10, 2024 · cancereffectsizeR quantifies selection for somatic variants in cancer from tumor sequencing data. See the package website for more information. WebApr 13, 2024 · Objective Recent studies indicated that transmembrane protein 40 (TMEM40) is associated with several types of cancers but is not clear in cervical cancer (CC). The study aimed to examine the role of TMEM40 in CC and related mechanisms. Methods The expression of TMEM40 in CC tissues and cell lines was studied with western blot and … software design methodology
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WebFeb 15, 2024 · Estimation of Neutral Mutation Rates and Quantification of Somatic Variant Selection Using cancereffectsizeR. Jeffrey D. Mandell; Vincent L. Cannataro; Jeffrey P. Townsend. An R package provides streamlined, customizable estimation of underlying nucleotide mutation rates and of the oncogenic and epistatic effects of mutations in … WebDec 5, 2024 · The utility of cancer effect was validated by showing in a pan-cancer dataset that somatic variants classified as likely pathogenic or pathogenic in ClinVar exhibit substantially higher effects... WebFeb 24, 2024 · build_RefCDS: cancereffectsizeR's RefCDS builder; calculate_trinuc_rates: Calculate trinuc rates; CESAnalysis: Create a cancereffectsizeR analysis; ces_epistasis: Variant-level pairwise epistasis; ces_gene_epistasis: Gene-level epistasis; ces_variant: Calculate cancer effects of variants; check_for_ref_data: check_for_ref_data software design online course